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Study details
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ARTEMIDE-Lung04 Trial

AstraZeneca
NCT IDNCT06868277ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

830

Study length

about 5.6 years

Ages

18+

Locations

31 sites in DE, FL, GA +14

What this study is about

Researchers are testing whether rilvegostomig or pembrolizumab monotherapy is effective as a first treatment for people with advanced non-small cell lung cancer whose tumors have high levels of PD-L1. The trial will last 2062 days and involve approximately 830 participants.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Receive Pembrolizumab
  • 2.Receive Rilvegostomig

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Injection / IV

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

pembrolizumab (Immune checkpoint inhibitor; blocks PD-1 to boost T-cell attack on cancer)

Drug routes

infusion

Endpoints

Primary: Overall Survival (OS), Progression-Free Survival (PFS)

Secondary: Duration of Response (DoR), Landmark Overall Survival (OS) rates, Landmark Progression-Free Survival (PFS) rates, Objective Response Rate (ORR), Patient-reported global health status (GHS)/quality of life (QoL), Patient-reported lung cancer symptoms of non-small cell lung cancer (NSCLC), Pharmakokinetics (PK) of rilvegostomig, Time to second progression or death (PFS2)

Body systems

Oncology