A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
Phase 1/2
150
about 4 years
18–70
14 sites in CA, FL, GA +7
What this study is about
This trial is testing a treatment called AZD0120 for adults with lupus that hasn't responded to other treatments. The goal is to see if it is safe, well-tolerated, and effective.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Receive AZD0120
- 2.Take Cyclophosphamide
- 3.Take Fludarabine
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
Assignment is predetermined by the study protocol.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
cyclophosphamide (Alkylating chemotherapy; crosslinks DNA strands), fludarabine
infusion
Primary: PHASE 1B: To evaluate the safety and tolerability of AZD0120 in participants with refractory systemic lupus erythematosus (SLE)
Secondary: PHASE 2: To assess changes from baseline for reported health-related quality of life, overall health status
Immune