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Study details
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Photon Craniospinal Irradiation for Leptomeningeal Disease

City of Hope Medical Center
NCT IDNCT06910761ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

35

Study length

about 3.4 years

Ages

18+

Locations

2 sites in CA

What this study is about

This trial is testing how well craniospinal irradiation (CSI) using photon volumetric modulated arc radiotherapy (VMAT) works in treating patients with breast cancer or non-small cell lung cancer that has spread to the brain and spinal cord. This treatment uses radiation therapy to kill tumor cells, potentially targeting all areas of possible leptomeningeal tumor spread.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Electronic Health Record Review
  • 2.Questionnaire Administration
  • 3.Receive Craniospinal Irradiation
  • +3 more

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Central nervous system (CNS)-progression free survival

Secondary: Incidence of adverse events, Overall survival, Quality of life, Radiographic response

Procedures

diagnostic, imaging

Body systems

Oncology