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Study details
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Buprenorphine Trial After Ankle Surgery

Jenna-Leigh Wilson
NCT IDNCT06949826ClinicalTrials.gov data as of Apr 2026
Phase

Phase 4

Target enrollment

100

Study length

about 2.2 years

Ages

18+

Locations

1 site in MO

What this study is about

This trial is testing whether a buprenorphine patch can help control pain after ankle surgery and reduce the risk of opioid addiction in patients who have never taken opioids before. Participants will use either a buprenorphine patch or a placebo patch for 800 days, while their pain management plan remains the same. It aims to determine if transdermal buprenorphine is safe and effective for managing postoperative pain after ankle fracture surgery.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Buprenorphine Transdermal System
  • 2.Take Placebo Patch

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
sublingualtransdermal

How treatment is administered

Treatment Assignment
Randomized & Blinded

You may get a placebo/standard care, and you won't know which.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

opioid partial agonist (Partial opioid agonist; relieves pain and treats opioid dependence)

Drug routes

sublingual, transdermal

Endpoints

Secondary: Emergency Department Presentations due to Opioid Toxicity, Emergency Department Presentations due to Uncontrolled Pain, Hospital Length of Stay, Hospital Readmissions due to Opioid Toxicity, Hospital Readmissions due to Uncontrolled Post-operative Pain, Number of Breakthrough Pain Episodes while Inpatient, Patient Satisfaction with Post-operative Pain Control, Prescription Pain Medication Misuse Short Form 7a Scores

Body systems

Psychiatry / Mental Health