Skip to content
Study details
Enrolling now

Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial

Roswell Park Cancer Institute
NCT IDNCT06995508ClinicalTrials.gov data as of Apr 2026
Phase

Phase 2

Target enrollment

66

Study length

about 5.8 years

Ages

18+

Locations

1 site in NY

What this study is about

This trial is testing whether adding olanzapine to standard care helps manage anorexia (loss of appetite) in head and neck cancer patients receiving chemoradiation. Olanzapine is a medication being studied for its potential to reduce nausea and improve appetite in these patients.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Best Practice
  • 2.Questionnaire Administration
  • 3.Take Olanzapine

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

olanzapine

Drug routes

oral (Oral Tablet)

Endpoints

Primary: Average change in weight

Secondary: Change in Quality of Life, Change in quality of life (QOL) scores, Hospitalization rate, Incidence of adverse events

Body systems

Oncology