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Study details
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Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy

Indiana University
NCT IDNCT06996951ClinicalTrials.gov data as of Apr 2026
Phase

Phase 3

Target enrollment

64

Study length

about 1.1 years

Ages

18+

Locations

1 site in IN

What this study is about

Researchers are testing whether people with Cystic Fibrosis on highly effective modulator therapy can stop using certain sinus treatments like nasal saline irrigation, steroid sprays, and antibiotic sprays. The trial will also examine changes in fluid inside the nose when these treatments are stopped.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take CONTINUE NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID
  • 2.Use STOP NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
intranasal

How treatment is administered

Treatment Assignment
Randomized (Open Label)

You are randomly assigned, but you will know your treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

corticosteroid

Drug routes

intranasal

Endpoints

Primary: Change in Body Mass Index (BMI), Change in Patient Health Questionnaire-9 (PHQ-9) Score

Body systems

Respiratory