Spironolactone Trial to Improve Pregnancy-Associated Hypertension
Phase 2
204
about 3.4 years
18+
Female only
3 sites in MA, PA
What this study is about
Researchers are testing whether spironolactone, a medication that blocks the mineralocorticoid receptor, can improve blood pressure and heart health in women who have had gestational hypertension or preeclampsia. The trial will last for 1233 days (about three years) after delivery.
Simplified from trial records by PatientMatch.
What you may be asked to do
- 1.Take Placebo tablet to match spironolactone
- 2.Take spironolactone 25 mg orally once daily
Participation Burden
What's physically and logistically required of participants.
Requires travel to a study site
How treatment is administered
You may get a placebo/standard care, and you won't know which.
Extracted study details
Pulled from the trial record to show what is being tested and what the study is measuring.
diuretic (Potassium-sparing diuretic; aldosterone antagonist)
oral (Oral Tablet), oral
Primary: Mean 24-hour ambulatory diastolic blood pressure
Secondary: Mean 24-hour ambulatory systolic blood pressure, Mean diurnal ambulatory diastolic blood pressure, Mean diurnal ambulatory systolic blood pressure, Mean nocturnal ambulatory diastolic blood pressure, Mean nocturnal ambulatory systolic blood pressure, Measured diastolic blood pressure, Measured systolic blood pressure, N-terminal pro-B-type natriuretic peptide
Reproductive Health, Cardiology / Heart