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Study details
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Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

St. Jude Children's Research Hospital
NCT IDNCT07226219ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1

Target enrollment

72

Study length

about 2.8 years

Ages

8–17

Locations

1 site in TN

What this study is about

Researchers are testing if a daily medication called Methylphenidate can help children with sickle cell disease improve their attention, thinking skills, and schoolwork. The trial will also look at any side effects of the medication and how parents make decisions about whether or not to use it.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Extended-Release Methylphenidate

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Oral

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

methylphenidate (CNS stimulant; blocks reuptake of dopamine and norepinephrine)

Drug routes

oral (Disintegrating Oral Tablet)

Endpoints

Secondary: Pediatric Quality of Life Inventory (PedsQL) Multidimensional Fatigue modules, Parent Report, Pediatric Quality of Life Inventory (PedsQL) Sickle Cell Disease modules, Parent Report

Body systems

Psychiatry / Mental Health