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Study details
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A Study of Amivantamab and Olomorasib Combination Therapy

Janssen Research & Development, LLC
NCT IDNCT07227025ClinicalTrials.gov data as of Apr 2026
Phase

Phase 1/2

Target enrollment

60

Study length

about 2.9 years

Ages

18+

Locations

6 sites in CA, NY, PA +3

What this study is about

This trial is testing the best dose of amivantamab and olomarasib, a combination treatment, for people with metastatic non-small cell lung cancer. The goal is to see how well this combination slows down or stops tumor growth.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take Amivantamab
  • 2.Take Olomorasib

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Drug classes

amivantamab

Endpoints

Primary: Phase 1: Number of Participants with Adverse Events (AEs) by Severity, Phase 2: Confirmed Objective Response Rate (ORR)

Secondary: Number of Participants with Adverse Events (AEs) by Severity, Phase 2: Disease Control Rate (DCR), Phase 2: Duration of Response (DoR), Phase 2: Overall Survival (OS), Phase 2: Progression-Free Survival (PFS)

Body systems

Oncology