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Study details
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Open-label Study to Evaluate Brain α-Synuclein Deposition Using PET and [18F]MK-0947 in Parkinson's Disease

Invicro
NCT IDNCT07348250ClinicalTrials.gov data as of Apr 2026
Phase

EARLY_PHASE1

Target enrollment

22

Study length

about 1.1 years

Ages

18–80

Locations

1 site in CT

What this study is about

This trial is testing a new imaging drug called [18F]MK-0947 to see if it can help doctors visualize changes in the brain related to Parkinson's disease (PD). The drug works with PET scans to show areas of the brain where α-synuclein builds up, which is linked to PD. The trial aims to determine if [18F]MK-0947 is safe and effective for visualizing α-synuclein in the brain.

Simplified from trial records by PatientMatch.

What you may be asked to do

  • 1.Take [18F]MK-0947

Participation Burden

What's physically and logistically required of participants.

Logistics & Travel
In-person visits

Requires travel to a study site

Physical Intervention
Standard

How treatment is administered

Treatment Assignment
All receive treatment

Everyone gets the investigational treatment.

Extracted study details

Pulled from the trial record to show what is being tested and what the study is measuring.

Endpoints

Primary: Safety of [18F]MK-0947: Incidence of Adverse Events

Secondary: Model-derived Pharmacokinetics of [18F]MK-0947

Body systems

Neurology